miRNA polymorphisms (miR-146a, miR-149, miR-196a2 and miR-499) are associated with the risk of coronary artery disease

• DOI: 10.3892/mmr.2016.5495
• Publication Date: 2016-07-11T04:08:14Z
• Authors: Jung-Hoon Sung; Sang-Hoon Kim; Woo-In Yang; Won-Jang Kim; Jae-Youn Moon; In Jai Kim; Dong-Hun Cha; Seung-Yun Cho; Jung Oh Kim; Kyeong Ah Kim; Ok-Joon Kim; Sang-Wook Lim; Nam-Keun Kim
• Keywords: Male; 0301 basic medicine; Genotype; Epistasis, Genetic; Coronary Artery Disease; Middle Aged; Polymorphism, Single Nucleotide; Severity of Illness Index; 3. Good health; MicroRNAs; 03 medical and health sciences; Percutaneous Coronary Intervention; Gene Frequency; Risk Factors; Case-Control Studies; Odds Ratio; Humans; Female; Genetic Predisposition to Disease; Alleles; Biomarkers; Genetic Association Studies; Aged

Small non‑coding microRNAs (miRNAs) are not only important for heart and vascular development but also in cardiovascular pathophysiology diseases, such as ischemia atherosclerosis‑related diseases. However, the effect of miR‑146a, miR‑149, miR‑196a2 miR‑499 polymorphisms on coronary artery disease (CAD) susceptibility remain unknown. The aim present study was to examine genotype frequencies patients with CAD, assess their clinical applications diagnosing monitoring CAD. Using polymerase chain reaction‑amplified DNA, microRNA were analyzed 522 CAD 535 control subjects. miR‑149 rs2292832 C>T rs11614913 T>C shown be significantly associated prevalence. In subgroup analyses according severity, miR‑146a rs2910164GG risk stent ≥2 group. addition, miR‑146aG/‑149T/‑196a2C/‑499 G allele combination prevalence (G‑T‑C‑G G‑C‑C‑G miR‑146a/‑149/‑196a2/‑499). genotypes miR‑146aGG/149TC+CC miR‑149CC/196a2TC incidence. analyses, rs2910164 C>G increased developing non‑smoking, hypertensive nondiabetic subgroups. Furthermore, increase females aged >63 years old. miR‑149T allele, miR‑196a2C pathogenesis. combined effects environmental factor miRNA may contribute