Correlation analysis between liver metastasis and serum levels of miR-200 and miR-141 in patients with colorectal cancer

• DOI: 10.3892/mmr.2017.7538
• Publication Date: 2017-09-20T07:22:08Z
• Authors: Meng Ding; Tao Zhang; Shijie Li; Ying Zhang; Yunfeng Qiu; Bin Zhang
• Keywords: Adult; Male; 0301 basic medicine; Liver Neoplasms; Apoptosis; Middle Aged; HCT116 Cells; Prognosis; 3. Good health; Gene Expression Regulation, Neoplastic; MicroRNAs; 03 medical and health sciences; Cell Movement; Case-Control Studies; Cell Line, Tumor; Disease Progression; Humans; Female; Neoplasm Grading; Colorectal Neoplasms; Aged

Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens prognosis colorectal cancer. MicroRNA (miR)‑200 miR‑141 have been confirmed to be aberrantly expressed in cancer, however, whether miR‑200 are involved progression their role remain fully elucidated. The aim present study was investigate patients. A total 380 patients were enrolled, which 142 diagnosed grade I/II 238 III/IV disease. Reverse transcription‑quantitative polymerase chain reaction analysis performed examine serum levels miR‑141. In addition, transfection HCT116 SW480 cells establish overexpression models for TUNEL assay assess apoptosis Transwell experiment cell migration. Compared control group, significantly increased group (P<0.05). without metastasis, had higher inhibited HC116 cells, enhanced upregulation associated Taken together, exacerbated via inhibiting inducing