The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

• DOI: 10.3892/mmr.2017.8141
• Publication Date: 2017-11-22T11:28:55Z
• Authors: Xueqiang Zhu; Hui Huang; Jun Zhang; Hao Liu; Rui Ao; Ming Xiao; Yuelei Wu
• Keywords: 0303 health sciences; Lung Neoplasms; Caspase 3; Cell Cycle; Ribosomal Protein S6 Kinases, 70-kDa; Antineoplastic Agents; Apoptosis; Caspase 9; Triterpenes; 3. Good health; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Proto-Oncogene Proteins c-akt; Cell Proliferation; Signal Transduction

The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth human non‑small lung cancer (NSCLC) and explore their mechanism. results indicated that the markedly attenuated proliferation, induced apoptosis in NSCLC. Furthermore, suppressed phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K), phosphorylation (p)‑AKT p‑p70S6K pathway Then, (PI3K) inhibitor increased In conclusion, inhibited NSCLC through PI3K/AKT/p70S6K signaling pathway.