Contribution of regulatory T�cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia

• DOI: 10.3892/mmr.2018.9733
• Publication Date: 2018-12-13T11:46:48Z
• Authors: Jiying Chen; Lijian Zhao; Dengchuan Wang; Yanbin Xu; Haijie Gao; Wenqing Tan; Chenhong Wang
• Keywords: Pathogenesis; Regulatory T cell

Increasing evidence suggests that an exaggerated maternal systemic inflammatofrery response may play a central role in the pathogenesis of preeclampsia (PE). Considering growing on microRNAs (miRNAs) and tissue‑specific regulators gene expression, we investigated potential association miR‑210 forkhead box p3 (Foxp3) preeclamptic patients. Serum levels cytokines interleukin (IL)‑6, IL‑10, IL‑17, transforming grown factor‑β1 were detected with ELISA. Reverse‑transcription‑quantitative polymerase chain reaction was performed to detect mRNA expression for placenta retinoic acid‑related orphan receptor C, Foxp3 miRNA (miR)‑210. protein evaluated by western blot analysis. IL‑10 significantly lower patients than normal pregnant women. PE. increased Results analysis indicated PE Our data suggest manifests as decreased number regulatory T cells (Tregs), which regulate tolerance fetus. In from women PE, compared women, decreased, increased.