Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway

• DOI: 10.3892/mmr.2021.11863
• Publication Date: 2021-01-24T17:13:10Z
• Authors: Dawei Cai; Jieling Wang; Sichun Chen; Longhai Jiang; Jinwei Chen; Ji Wu; Jian Qin
• Keywords: MMP3

Osteoarthritis (OA) is the most prevalent joint disorder characterized by progressive cartilage damage, resulting in gradual disability among elderly. We previously provided <em>in vivo</em> evidence that nuclear factor erythroid 2‑related 2 (Nrf2) deficiency associated with development of OA. It has been reported coniferaldehyde (CFA) acts as a potential Nrf2 activator. The aim present study was to investigate protective effects CFA against osteoarthritis. A murine model surgical‑induced OA used and administered peritoneal injection every day, knee joints were assessed histological analysis. results demonstrated activated signaling pathway primary chondrocytes articular from joints. Cartilage damage mice subjected destabilization medial meniscus evidently alleviated treatment. also robustly suppressed apoptosis induced H2O2 reduced expression matrix metalloproteinase (MMP)1, MMP3, interleukin (IL)‑1 IL‑6 vivo. On whole, findings suggested exerts therapeutic effect OA, activation Nrf2/heme oxygenase‑1 may play crucial role CFA‑mediated protection.