circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR‑199‑3p expression

• DOI: 10.3892/mmr.2021.12426
• Publication Date: 2021-09-08T11:32:29Z
• Authors: Yu Sun; Guangtao Ma; Hongtao Xiang; Xiaomin Wang; Hanmei Wang; Yan Zhang; Fuzhong Qie; Chenlong Li
• Keywords: U87

Glioblastoma (GBM) is one of the most common and malignant types primary cancer in central nervous system; however, clinical outcomes patients with GBM remain poor. Circular RNAs (circRNAs) have been revealed to serve important roles diverse biological processes, such as regulating cell proliferation, epithelial‑mesenchymal transition tumor development. However, underlying function circRNA filamin A (circFLNA) its potential role be determined. The present study aimed identify differentially expressed circRNAs GBM. Reverse transcription‑quantitative PCR was used analyze expression levels circFLNA. results demonstrated that circFLNA were significantly upregulated samples cells compared adjacent healthy brain tissues normal human astrocytes, respectively. Cell Counting Kit‑8 Transwell assays knockdown inhibited proliferative invasive abilities lines. Moreover, high associated a worse prognosis MicroRNA (miR)‑199‑3p subsequently predicted target inhibitory effect miR‑199‑3p on proliferation invasion partially reversed following knockdown. In conclusion, findings identified novel for indicated circFLNA/miR‑199‑3p signaling axis may an progression. Therefore, represent diagnosis treatment