Copy number alterations and epithelial‑mesenchymal transition genes in diffuse and intestinal gastric cancers in Mexican patients

• DOI: 10.3892/mmr.2022.12707
• Publication Date: 2022-03-31T09:24:01Z
• Authors: Violeta Larios‑Se...; José-Darío Martín...; Hilda-Alicia Vald...; Javier Torres; Margarita Camorli...; Patricia Piña‑Sán...; Martha-Eugenia Ru...
• Keywords: Gene Expression Regulation, Neoplastic; 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Epithelial-Mesenchymal Transition; DNA Copy Number Variations; Stomach Neoplasms; Computational Biology; Humans; Articles; Mexico; 3. Good health

Gastric cancer (GC) is a common malignancy with the highest mortality rate among diseases of digestive system, worldwide. The present study GC alterations crucial to understanding tumor biology and establishment important aspects prognosis treatment response. In study, DNA from Mexican patients diffuse (DGC), intestinal (IGC) or non‑atrophic gastritis (NAG; control) was purified whole‑genome analysis performed high‑density arrays. Shared unique copy number (CNA) were identified between different tissues involving key genes signaling pathways associated cancer. This led molecular distinction identification most relevant functions be identified. A more detailed bioinformatics epithelial‑mesenchymal transition (EMT) revealed that altered network chromosomal included 11 shared DGC, IGC NAG, as well 19 DGC‑ 7 IGC‑exclusive genes. Furthermore, main adhesion, angiogenesis, migration, metastasis, morphogenesis, proliferation survival. provided first array in exclusive CNA‑associated DGC IGC. addition, bioinformatics‑predicted generated, focusing on CNA‑altered EMT hallmarks cancer, precancerous may lead GC. Molecular signatures GC, predicted bioinformatically, involve distinct CNA‑EMT related are potential candidates for screening biomarkers including early stages.