A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats

• DOI: 10.3892/mmr.2023.13119
• Publication Date: 2023-10-27T12:32:50Z
• Authors: Aristidis Tsatsakis; Elisavet Renieri; Dimitris Tsoukalas; Ana Buga; Evangelia Sarandi; Elena Vakonaki; Persefoni Fragkia...; Athanasios Alegakis; Dragana Nikitovic; Daniela Calina; Demetrios Spandidos; Anca Docea
• Keywords: Nutraceutical; Biorepository

Telomeres are major contributors to cell fate and aging through their involvement in cycle arrest senescence. The accelerated attrition of telomeres is associated with aging‑related diseases, agents able maintain telomere length (TL) telomerase activation may serve as potential treatment strategies. aim the present study was assess potency a novel activator on TL activity vivo. administration nutraceutical formulation containing Centella asiatica extract, vitamin C, zinc D3 18‑month‑old rats for period 3 months reduced shortening rate at lower supplement dose increased mean higher dose, compared pre‑treatment levels. determined using Q‑FISH method peripheral blood mononuclear cells collected from tail vein cultured RPMI‑1640 medium. In both cases, TLs were significantly longer untreated controls (P≤0.001). addition, groups. On whole, demonstrates that can or even increase middle‑aged rats, indicating role this formula prevention diseases.