Therapeutic strategies targeting the NLRP3‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review)

• DOI: 10.3892/mmr.2024.13170
• Publication Date: 2024-01-22T12:40:17Z
• Authors: Wan-Li Duan; Xue-Jie Wang; Ya-Ping Ma; Zhi-Mei Sheng; Hao Dong; Li-Ying Zhang; Bao-Gang Zhang; Mao-Tao He
• Keywords: Pyroptosis

Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need be further clarified, and associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain 3 (NLRP3) inflammasome serves an important role in causing CIRI, its activation exacerbates underlying injury. Activation NLRP3 triggers maturation production inflammatory molecules IL‑1β IL‑18, as well gasdermin‑D‑mediated pyroptosis CIRI damage. Thus, may viable target for CIRI. In present review, intense response induced by are discussed, therapeutic strategies that NLRP3‑mediated summarized. At present, certain drugs have already been studied, highlighting future perspectives.