Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)

• DOI: 10.3892/mmr.2024.13220
• Publication Date: 2024-04-09T11:36:47Z
• Authors: Chucun Fang; Feng Huang; Mengting Yao; Zilong Wang; Jiacheng Ma; Dongwen Wu; Tianting Guo; Fei Zhang; Jianwen Mo
• Keywords: Pathogenesis

Deep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into circulatory system, giving rise complications such as pulmonary embolism, thereby posing significant risk patient. Virchow proposed blood stagnation, alterations vessel wall and hypercoagulation are primary factors contributing development of thrombosis. Vascular endothelial cells (VECs) constitute initial barrier vascular focal point ongoing research. These exert diverse stimulatory effects on bloodstream secrete various regulatory uphold dynamic equilibrium between coagulation anticoagulation processes. MicroRNAs (miRNAs) represent class non‑coding RNAs present eukaryotes, characterized by genetic evolutionary conservation displaying high spatiotemporal expression specificity. Typically ranging from 20 25 bases length, miRNAs can influence downstream gene transcription through RNA interference binding specific mRNA sites. Consequently, advancements understanding molecular mechanisms miRNAs, including their functionalities, involve modulation vascular‑associated processes cell proliferation, differentiation, secretion inflammatory factors, migration, apoptosis remodeling regeneration. play substantial role DVT formation via VECs. In review, distinct functions outlined recent progress comprehending pathogenesis application elucidated.