Significant expression of CHK1 and p53 in bladder urothelial carcinoma as potential therapeutic targets and prognosis

• DOI: 10.3892/ol.2017.7344
• Publication Date: 2017-11-03T07:57:57Z
• Authors: Linfeng Zheng; Yuping Zhu; Lei Lei; Wenyong Sun; Guoping Cheng; Shifeng Yang
• Keywords: CHEK1

Checkpoint kinase 1 (CHK1) and p53 are involved in cell‑cycle checkpoint, cellular response to DNA damage. CHK1 overexpressed bladder urothelial carcinoma (BUC); however, a clear elucidation on their interaction influence the progress of BUC is absent. The aim present study was examine correlation between BUC, analyze value as therapeutic targets prognostic indicators BUC. A clinically annotated cohort 110 patients with identified retrospectively. EnVision‑based immunohistochemistry western blot analysis aforementioned repair proteins were conducted formalin‑fixed‑paraffin‑embedded or frozen tissues from primary tumor. total 45 peritumoral tissue cases assessed similarly control group. In significant overexpression observed compared (P<0.05). demonstrated positive both positively associated histological grade, clinical pathological staging, lymphatic metastasis 5‑year survival rate However, not sex, age, tumor diameter, single/multiple sites incipient/recurrence. p53, synergistic putatively correlated physiology that may be deemed potential indicators.