Ki67 testing in the clinical management of patients with non‑metastatic colorectal cancer: Detecting the optimal cut‑off value based on the Restricted Cubic Spline model

• DOI: 10.3892/ol.2022.13540
• Publication Date: 2022-10-07T05:34:42Z
• Authors: Hong Lei; Shan Yan; Yin He; Ning Xu; Min Zhao; Chun Yu; Hong Li; Sai Kuang; Zhan Cui; Jing Fang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Articles; 3. Good health

The proliferation of the biomarker Ki67 has been extensively studied in colorectal cancer (CRC). Although numerous cut-off values have previously reported, optimal value remains unclear with previous studies providing contrasting results. present retrospective cohort study aimed to determine for CRC. levels and prognosis patients non-metastatic CRC were obtained from Electronic Health Information System a tertiary hospital Kunming City. Restricted Cubic Spline (RCS) model was used analyze non-linear association between risk patient death metastasis. Moreover, RCS Ki67. Cox proportional hazards models verify effects value. In total, 210 median age 62.5 years (age range, 23.0-88.0 years) studied. Results demonstrated based on model, at ≥60%, hazard ratio (HR) gradually increased. Using multivariate-adjusted models, results that ≥60% indicated high-risk both distant metastasis [HR, 2.640; 95% confidence interval (CI), 1.066-6.539], compared <60% (HR, 2.558; CI, 1.079-6.064). Therefore, may be prediction Thus, act as predicting CRC, is 60%.