Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

• DOI: 10.3892/ol.2024.14287
• Publication Date: 2024-02-14T13:49:40Z
• Authors: Dan Zhang; Jingjing Jin; Jianying Dou; Yan Huang; Haibo Zhang
• Keywords: Chemoradiotherapy; Respiratory tract

Lung cancer is a prevalent and highly lethal disease often complicated by lower respiratory tract infections. Microbial patterns in these infections vary based on treatment modalities. The present study explored the impact of lung treatments pathogens clinical characteristics presence to inform antimicrobial drug selection. A retrospective analysis was performed that included data from 93 patients diagnosed with advanced between January 2019 December 2021. Patients were divided into targeted therapy chemoradiotherapy groups. Clinical, nutritional, biochemical, infection pathogenetic indicators compared. Of cases, 24 group 69 group. Pathological type hospitalization duration differed significantly (P&lt;0.05), but age, sex, smoking history, alcohol consumption underlying diseases did not (P&gt;0.05). Lymphocyte counts while body mass index, albumin, hemoglobin, alanine aminotransferase creatinine levels, erythrocyte sedimentation rate, hypersensitive C‑reactive protein procalcitonin percentage neutrophils Pathogenetic testing negative 15 positive 78 patients, Gram‑negative bacteria (61.77%), fungi (17.65%) viruses (11.76%) predominant In group, (47.46%), (28.81%) (16.95%) also more prevalent. <em>Candida albicans</em> most frequent fungal both groups, mixed common (50% 73.92% chemoradiotherapy). had (P&lt;0.05). Overall, groups bacteria, viruses. Chemoradiotherapy experienced longer hospital stays higher incidence infections, predominantly involving fungi. results provide valuable insights rational selection empirical antibiotics antifungals for critically ill or chemoradiotherapy.