microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS

• DOI: 10.3892/or.2013.2807
• Publication Date: 2013-10-23T08:48:08Z
• Authors: LINAN ZHU; ZHIJU WANG; QINGXIA FAN; RUILIN WANG; YAN SUN
• Keywords: Male; Mice, Inbred BALB C; 0303 health sciences; Esophageal Neoplasms; Down-Regulation; Mice, Nude; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; 03 medical and health sciences; Cell Transformation, Neoplastic; Cell Movement; Cell Line, Tumor; Gene Knockdown Techniques; Lymphatic Metastasis; Carcinoma, Squamous Cell; Animals; Humans; Genes, Tumor Suppressor; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; 3' Untranslated Regions; Cell Proliferation

microRNAs (miRNAs) have been suggested to play a vital role in regulating tumor progression and invasion. However, the expression of miR-27a esophageal squamous cell carcinoma (ESCC) its effect on tumorigenesis ESCC are unclear. In present study, we found that was downregulated lines specimens with lymph node metastasis. Furthermore, demonstrated binds 3'-untranslated region (UTR) KRAS inhibits protein. levels were inversely correlated mRNA protein specimens. Both vitro vivo assays revealed attenuated proliferation, invasion growth nude mice. exerts suppressor function through inhibition KRAS-related ERK pathways. Our findings suggest, for first time, suppresses by targeting KRAS.