MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma

• DOI: 10.3892/or.2016.5290
• Publication Date: 2016-12-05T10:35:58Z
• Authors: Jiejing Zhou; Yanjun Zhang; Yuhong Qi; Dequan Yu; Qiuju Shao; Jun Liang
• Keywords: Liver Cancer

Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% all cases primary annually. Rhotekin (RTKN), which functions as a promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal bladder carcinoma. The aim this study was to investigate role RTKN HCC. Using HCC cells tissues from patients with we demonstrated that significantly increased To examine effect on HCC, overexpressed or silenced HepG2 Hep3B were constructed. Cell proliferation apoptosis measured by RT-PCR flow cytometry. results showed function an oncogene promote proliferation, while inhibiting apoptosis, cells. Furthermore, identified direct gene target miR-152. miR-152 reverse growth promoting through G2/M phase arrest nuclear factor-κB (NF-κB) signal inhibition. In conclusion, our research miRNA-152 inhibit tumor cell targeting