MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis

• DOI: 10.3892/or.2017.5579
• Publication Date: 2017-04-19T07:43:00Z
• Authors: Yarui Li; Mudan Ren; Yan Zhao; Xinlan Lu; Mengyao Wang; Junbi Hu; Guifang Lu; Shuixiang He
• Keywords: MEG3; DNMT3B; DNMT1

miR-26a is known to play an important oncosuppressive role in HCC. However, its regulatory and relationship with other non-coding RNAs less clear. In the present study, we report that expression levels of long RNA (lncRNA) maternally expressed gene 3 (MEG3) were frequently downregulated HCC tissues compared matched non-malignant tissues. addition, MEG3 negatively correlated tumor sizes TNM clinical stage patients. Overexpression significantly reduced capacity proliferation, invasion migration cells. Moreover, demonstrated DNA methyltransferase 3b (DNMT3B) was a direct target miR-26a. suppressed level DNMT3B. Inhibited DNMT3B showed similar suppressive effects induced by upregulation, resulted upregulation MEG3. Furthermore, found upregulated tissues, it inversely Thus, these results provided plausible link between observed reduction HCCs. Together, study added miR-26a/DNMT3B/MEG3 axis complex mechanisms development.