Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor

• DOI: 10.3892/or.2017.5676
• Publication Date: 2017-05-30T01:00:46Z
• Authors: Xiang-Feng Liu; Hai-Jiao Long; Xiong-Ying Miao; Guo-Li Liu; Hong-Liang Yao
• Keywords: Fisetin; Liver Cancer; Tumor progression

Fisetin (3,3',4',7-tetrahydroxyflavone), a natural abundant flavonoid, is produced in different vegetables and fruits. has been reported to relate various positive biological effects, including anti-proliferative, anticancer, anti-oxidative neuroprotective effects. Dopamine receptors (DRs) belonging G protein‑coupled receptor family, are known as the target of ~50% all modern medicinal drugs. DRs consist proteins, functioning transduction intracellular signals for extracellular stimuli. We found that fisetin performed DR2 agonist suppress liver cancer cells proliferation, migration invasion. Caspase-3 signaling was activated induce apoptosis administration. Furthermore, TGF‑β1 also inhibited fisetin-treated cells, reducing epithelial-mesenchymal transition (EMT). Additionally, downregulated VEGFR1, p-ERK1/2, p38 pJNK, ameliorating progression. In vivo, orthotopically implanted tumors from mice were by adminisatration accompanied prolonged survival rate higher levels dopamine. Together, results indicated novel therapeutic strategy progression associated with regulation, indicating dopamine might be importance