BAF53a is a potential prognostic biomarker and promotes invasion and epithelial-mesenchymal transition of glioma cells

• DOI: 10.3892/or.2017.6019
• Publication Date: 2017-10-10T10:42:08Z
• Authors: Li Meng; Xiaoyi Wang; Weihua Liao; Jianling Liu; Yiwei Liao; Qiongqiong He
• Keywords: Tumor progression

Increasing evidence indicates that BAF53a is crucial for embryonic development and maintenance of stemness, may be associated with epithelial-mesenchymal transition (EMT), which suggests its involvement in cancer progression. However, the role glioma remains unknown. In present study, was found to highly expressed tissues poor overall survival (OS) progression-free (PFS) patients. A multivariate Cox regression analysis revealed might an independent prognostic factor OS PFS Further functional indicated overexpression could promote proliferation increase motility invasion U87 cells, whereas knockdown had opposite effect. addition, expression levels E‑cadherin vimentin tissues. This further confirmed cells expressing different BAF53a; concomitant decreased increased expression, showed pattern expression. Taken together, these results suggest a novel patients, BAF53 facilitate progression by promoting proliferation, invasion, associate EMT. Therefore, potential promising biomarker target treatment glioma.