MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1

• DOI: 10.3892/or.2020.7809
• Publication Date: 2020-10-15T07:11:27Z
• Authors: Chi Zhang; Qi Wang; Xiaowen Zhou; Lei Zhang; Ying Yao; Juan Gu; Huairui Chen; Jun Qian; Chun Luo; Qingke Bai; Guohan Hu
• Keywords: Male; 0301 basic medicine; Brain Neoplasms; TOR Serine-Threonine Kinases; Brain; Apoptosis; Articles; Glioma; Kaplan-Meier Estimate; Middle Aged; Gene Expression Regulation, Neoplastic; MicroRNAs; 03 medical and health sciences; HEK293 Cells; Cell Movement; Cell Line, Tumor; Humans; Female; Neoplasm Invasiveness; Cyclic AMP Response Element-Binding Protein; Cell Proliferation; Signal Transduction

Alterations in the expression of microRNA (miR)‑138 have been demonstrated to result development several malignant tumours. However, possible function miR‑138 human glioma cells remains unclear. The present study that was significantly downregulated 48 specimens by quantitative PCR analysis. upregulation exerted significant antiproliferative and anti‑invasive effects on promoted their apoptosis. In addition, cAMP response element‑binding protein 1 (CREB1) confirmed as a direct target gene luciferase reporter assay, antitumour effect reversed CREB1 overexpression. Moreover, molecular mechanisms underlying tumour‑suppressive role may be associated with dephosphorylation AKT/mTOR caused upregulation‑induced decrease cells. results indicated affect CREB1/AKT/mTOR signalling regulate proliferation, apoptosis invasion progression glioma, thereby suggesting potential for treatment gliomas.