miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

• DOI: 10.3892/or.2023.8487
• Publication Date: 2023-01-20T09:32:10Z
• Authors: Yaya Xie; Yue Zhang; Xianju Liu; Lijun Cao; Mengting Han; Chunmei Wang; Jinlian Chen; Xingxing Zhang
• Keywords: Ectopic expression

Colorectal carcinoma (CRC) is one of the most common types digestive cancer. It has been reported that ectopic expression microRNAs (miRs) plays a critical role in occurrence and progression CRC. In addition, it also suggested miR‑151a‑5p may serve as useful biomarker for early detection treatment different cancer particularly However, specific effects underlying mechanisms CRC remain elusive. The results current study demonstrated was upregulated cell lines clinical tissues derived from patients with Functionally, showed significantly promoted proliferation, migration invasion. Additionally, dual luciferase reporter assays verified agmatinase (AGMAT) direct target positively associated expression. Mechanistically, could enhance epithelial‑mesenchymal transition cells. Taken together, revealed novel molecular mechanism indicating miR‑151a‑5p/AGMAT axis crucial regulation therefore be considered potential therapeutic strategy