MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression

• DOI: 10.3892/or.2023.8546
• Publication Date: 2023-04-13T07:45:27Z
• Authors: Rhafaela Causin; André Van Helvoor...; Izabela Gomes; Ana De Freitas; Marcela Rosa; Ricardo Dos Reis; Rui Reis; Márcia Marques
• Keywords: HeLa

MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, mechanisms underlying their actions cancer remain unclear. The present study aimed to evaluate functional role miR‑130a‑3p Cervical cells were transfected with a miRNA inhibitor (anti‑miR‑130a‑3p) negative control. Adhesion‑independent cell proliferation, migration invasion evaluated. findings presented herein demonstrated that was overexpressed HeLa, SiHa, CaSki, C‑4I HCB‑514 cells. inhibition significantly reduced canonical delta‑like Notch1 ligand (<em>DLL1</em>) identified as possible direct target miR‑103a‑3p. <em>DLL1</em> gene further found be downregulated tissues. On whole, demonstrates contributes Therefore, may used biomarker determine progression.