Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma

0301 basic medicine Lymphokines Thymidine Phosphorylase Neovascularization, Pathologic Macrophages Microcirculation Antigens, Differentiation, Myelomonocytic Cell Differentiation Epithelial Cells Endothelial Growth Factors 3. Good health Immunoenzyme Techniques 03 medical and health sciences 0302 clinical medicine Antigens, CD Cell Movement Lymphatic Metastasis Proliferating Cell Nuclear Antigen Carcinoma, Squamous Cell Humans Intercellular Signaling Peptides and Proteins Mouth Neoplasms Neoplasm Invasiveness Neoplasm Staging
DOI: 10.3892/or.9.6.1219 Publication Date: 2014-03-10T07:45:55Z
ABSTRACT
Tumor-associated macrophages (TAMs) have been shown to display both positive and negative effects on tumor growth of various cancer. In this study, TAMs were immunohistochemically labeled using CD68 antibody in 82 oral cancer. Macrophage index (MI) were analyzed in association with clinical and pathological factors, intratumoral microvessel density (IMVD) and angiogenic factors including VEGF and TP. Significantly higher number of CD68-positive cells was noted in oral cancer. TAM expressions were significantly associated with stages of invasion, IMVD, and angiogenic factors. These findings suggest that TAMs possibly play a role in angiogenesis during oral cancer progression.
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