Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma
0301 basic medicine
Lymphokines
Thymidine Phosphorylase
Neovascularization, Pathologic
Macrophages
Microcirculation
Antigens, Differentiation, Myelomonocytic
Cell Differentiation
Epithelial Cells
Endothelial Growth Factors
3. Good health
Immunoenzyme Techniques
03 medical and health sciences
0302 clinical medicine
Antigens, CD
Cell Movement
Lymphatic Metastasis
Proliferating Cell Nuclear Antigen
Carcinoma, Squamous Cell
Humans
Intercellular Signaling Peptides and Proteins
Mouth Neoplasms
Neoplasm Invasiveness
Neoplasm Staging
DOI:
10.3892/or.9.6.1219
Publication Date:
2014-03-10T07:45:55Z
AUTHORS (5)
ABSTRACT
Tumor-associated macrophages (TAMs) have been shown to display both positive and negative effects on tumor growth of various cancer. In this study, TAMs were immunohistochemically labeled using CD68 antibody in 82 oral cancer. Macrophage index (MI) were analyzed in association with clinical and pathological factors, intratumoral microvessel density (IMVD) and angiogenic factors including VEGF and TP. Significantly higher number of CD68-positive cells was noted in oral cancer. TAM expressions were significantly associated with stages of invasion, IMVD, and angiogenic factors. These findings suggest that TAMs possibly play a role in angiogenesis during oral cancer progression.
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