Increased Concentrations of Prostaglandin D2During Post-Fracture Bone Remodeling

• DOI: 10.3899/jrheum.090622
• Publication Date: 2010-01-16T01:54:45Z
• Authors: MAXIME A. GALLANT; ESTELLE CHAMOUX; MARTINE BISSON; CATARINA WOLSEN; JEAN-LUC PARENT; SOPHIE ROUX; ARTUR J. de BRUM-...
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Middle Aged; Alkaline Phosphatase; Dinoprost; Bone and Bones; Collagen Type I; Dinoprostone; Lipocalins; Peptide Fragments; Intramolecular Oxidoreductases; Fractures, Bone; 03 medical and health sciences; Case-Control Studies; Homeostasis; Humans; Female; Bone Remodeling; Peptides; Procollagen

Objective.To test the hypothesis that increased concentrations of prostaglandin D2(PGD2) correlate with bone remodeling. Studies using isolated bone cells indicate that PGD2may be implicated in the regulation of bone homeostasis, with a positive influence on bone anabolism. We studied patients with traumatic fractures and age- and sex-matched healthy controls as anin vivomodel of increased bone remodeling.Methods.Thirty-five patients with bone fracture and matched controls were recruited. Urine and sera samples were collected. Urinary 11ß-PGF2α, a PGD2metabolite, and PGE2metabolites (PGEM), serum lipocalin-type PGD2synthase (L-PGDS), bone alkaline phosphatase (bone ALP), and crosslinked C-telopeptides of type I collagen (CTX) were measured.Results.At 5–6 weeks post-fracture, 11ß-PGF2α, L-PGDS, bone ALP, and CTX were significantly increased in the fracture patients compared to controls. PGEM levels were not different between groups. Levels of 11ß-PGF2αand bone ALP were positively correlated, suggesting that PGD2may be implicated in fracture repair.Conclusion.These results support our working hypothesis that PGD2could be implicated in the control of bone anabolism in humans.