The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients

• DOI: 10.3906/sag-1803-13
• Publication Date: 2019-02-14T06:48:45Z
• Authors: Canan ALBAYRAK; Pınar TARKUN; Elif BİRTAŞ ATEŞOĞLU; Ceyla ERALDEMİR; Özgür Doğa ÖZSOY; Esra TERZİ DEMİRSOY; Özgür MEHTAP; Ayfer GEDÜK
• Keywords: Adult; Male; 0301 basic medicine; Growth Differentiation Factor 15; Iron; Middle Aged; Article; Mitochondrial Proteins; 03 medical and health sciences; Hepcidins; Case-Control Studies; Humans; Female; Cation Transport Proteins; Polycythemia Vera; Aged; Thrombocythemia, Essential

GDF15, hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There are no studies in the literature demonstrating the serum mfrn-1 levels in polycythemia vera (PV) and essential thrombocythemia (ET) patients. The aim of this study was to investigate GDF15, hepcidin and mfrn-1 levels in PV and ET patients.Ten PV, 17 ET patients, and 27 healthy controls (HCs) were enrolled. GDF15, hepcidin and mfrn-1 values were measured with enzyme-linked immunosorbent assay (ELISA).GDF15 levels were higher in the myeloproliferative neoplasm (MPN) group (P = 0.002). Hepcidin levels were not different between MPN patients and HCs. The mfrn-1 levels were lower in MPN patients (P = 0.039). Hepcidin, GDF15, and mfrn-1 levels were not different between PV and ET patients. mfrn-1 levels were lower in ET patients than HCs (P = 0.038).Increased erythropoiesis in MPNs may lead to high GDF15 levels in these patients. However, hepcidin was not suppressed despite the increased GDF15 levels and erythropoiesis in these patients. Decrease in mfrn-1 in MPNs can be the result of its increased turnover due to increased myelopoiesis. It can be hypothesized that similar hepcidin levels in patients and controls and low mfrn-1 levels in patients may be a defense mechanism against erythroid activity and thromboembolic complications.