Optimal strategy for a dose-escalation vaccination against COVID-19 in refugee camps

• DOI: 10.3934/math.2022515
• Publication Date: 2022-03-10T10:13:57Z
• Authors: Qinyue Zheng; ; Xinwei Wang; Qiuwei Pan; Lei Wang
• Keywords: Vaccine efficacy

<abstract> <p>An immunogenic and safe vaccine against COVID-19 for use in the healthy population will become available near future. In this paper, we aim to determine optimal administration strategy refugee camps considering maximum daily limited total supply. For purpose, extended SEAIRD compartmental models are established describe epidemic dynamics with both single-dose double-dose administration. Taking vaccination rates different susceptible compartments as control variables, problems then solved under framework of nonlinear constrained problems. To best our knowledge, is first paper that addresses an practical constraints on medical care resources. Numerical simulations show strategies can successfully COVID-19. By comparison, achieve a better reduction infection death, while postpone peak more efficiently. Further studies influence parameters indicate increasing number personnel supply greatly contribute fight The results study instructive potential forthcoming Moreover, work provides general developing presence resources.</p> </abstract>