Aqueous Diels-Alder Reactions of Electron Deficient 2-Arylfurans: A Highly Stereoselective Route to 2,2,5-Trisubstituted Tetrahydrofurans towards a Novel Class of Orally Active Azole Antifungals

• DOI: 10.3987/com-92-s45
• Publication Date: 2009-03-04T05:09:33Z
• Authors: Anil K. Saksena; Viyyoor M. Girija...; Yao-Tsung Chen; Edwin Jao; Russell E. Pike; Jagdish A. Desai; Dinanath Rane; Ashit K. Ganguly
• Keywords: Azole; Orally active

with either I or 6-under the abovenon-aqueous conditions36 failedio provide desired adducts.Wc have not studied these reactions under Lewis acid catalysis high pressure conditions.