Drug-Induced Parkinsonism

• DOI: 10.3988/jcn.2012.8.1.15
• Publication Date: 2012-04-06T01:52:14Z
• Authors: Hae-Won Shin; Sun Ju Chung
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Review; 3. Good health

Drug-induced parkinsonism (DIP) is the second-most-common etiology of in elderly after Parkinson's disease (PD). Many patients with DIP may be misdiagnosed PD because clinical features these two conditions are indistinguishable. Moreover, neurological deficits severe enough to affect daily activities and persist for long periods time cessation drug taking. In addition typical antipsychotics, caused by gastrointestinal prokinetics, calcium channel blockers, atypical antiepileptic drugs. The manifestations classically described as bilateral symmetric without tremor at rest. However, about half show asymmetrical rest, making it difficult differentiate from PD. pathophysiology related drug-induced changes basal ganglia motor circuit secondary dopaminergic receptor blockade. Since effects limited postsynaptic receptors, expected that presynaptic neurons striatum will intact. Dopamine transporter (DAT) imaging useful diagnosing parkinsonism. DAT uptake significantly decreased even early stage PD, this characteristic help differentiating DIP. have a significant longstanding effect on patients' lives, so physicians should cautious when prescribing blockers monitor signs, especially other movement disorders.