Effect of Repetitive Transcranial Magnetic Stimulation on Seizure Frequency and Epileptiform Discharges in Drug-Resistant Epilepsy: A Meta-Analysis

• DOI: 10.3988/jcn.2020.16.1.9
• Publication Date: 2020-01-14T23:40:50Z
• Authors: Archana Mishra; Rituparna Maiti; Biswa Ranjan Mishra; Monalisa Jena; Anand Srinivasan
• Keywords: Meta-regression

The role of low-frequency repetitive transcranial stimulation (rTMS) in drug-resistant epilepsy (DRE) has been conflicting and inconclusive previous clinical trials. This meta-analysis evaluated the efficacy rTMS on seizure frequency epileptiform discharges DRE.A standard protocol was registered International Prospective Register Ongoing Systematic Reviews (PROSPERO: CRD42018088544). After performing a comprehensive literature search using specific keywords MEDLINE, Cochrane database, Clinical Trial Registry Platform (ICTRP), reviewers assessed eligibility extracted data from seven relevant Preferred Reporting Items for Meta-Analysis (PRISMA) guidelines were followed selection, analysis, reporting findings. A random-effects model used to estimate effect size as mean difference interictal between groups. Quality assessment performed risk-of-bias tool, meta-regression identify variables that probably influenced size.The analysis revealed pooled -5.96 (95% CI= -8.98 -2.94), significantly favoring (p=0.0001) over control group with regard frequency. overall also favored (p<0.0001), an -9.36 CI=-13.24 -5.47). In meta-regression, worsened by 2.00±0.98 (mean±SD, p=0.042) each week-long lengthening posttreatment follow-up period, suggesting exerts only short-term effect.This shows significant beneficial DRE reducing both discharges. However, ephemeral rTMS.