Consecutive multi-component syntheses of heterocycles via palladium-copper catalyzed generation of alkynones

• DOI: 10.3998/ark.5550190.0009.107
• Publication Date: 2012-10-01T20:36:43Z
• Authors: Benjamin Willy; Thomas J. J. Müller
• Keywords: Component (thermodynamics)

Alkynones are prominent three-carbon building blocks in heterocyclic chemistry.They can be generated very easily and efficiently by modified Sonogashira coupling of acid chlorides terminal alkynes.Mild reaction conditions now set the stage for new diversity-oriented routes to heterocycles sequential consecutive transformations.Hence, isoxazoles, indolizines, pyrazoles, pyridimines, 1,5-benzoheteroazepines, furans, oxazoles, tetrahydro-β-carbolines accessible coupling-cycloaddition or coupling-addition-cyclocondensation multi-component sequences.