Histological investigation of α-lipoic acid in the wound healing process of diabetic lesions in vivo

• DOI: 10.4025/actascibiolsci.v47i1.73374
• Publication Date: 2025-05-06T17:55:22Z
• Authors: Guilherme Fernand...; Vithoria Régia Te...; Andreza Gyslaynny...; Kelvi Wilson Evar...; Claudio Gleidisto...; Woneska Rodrigues...; Luis Rafael Leite...

α-Lipoic acid (ALA) is a significant therapeutic agent for inflammation. Understanding the histological parameters involved in healing process influenced by inflammatory activity crucial developing new technologies to treat wounds caused diabetes mellitus. This study diabetic Wistar rats, divided into groups based on treatment: control group (distilled water and cellulose), 100 mg.kg-1 dose of α-lipoic acid, 200 mg kg-1 dose. Diabetes was experimentally induced, lesions were created rats’ backs. The received oral doses 100-200 kg-1, while distilled with cellulose. Wounds later excised subjected analysis. exhibited ‘mild’ ‘absent’ chronic responses, showed similar results acute treatments, all analyzed parameters. reduced examined, lower demonstrating beneficial effects during continuous treatment. In contrast, yielded indicating effectiveness treatments. Further studies are required explore absorption ALA vivo models.