Hollow Gold Nanoparticals as Biocompatible Radiosensitizer: An <i>In Vitro</i> Proof of Concept Study

• DOI: 10.4028/www.scientific.net/jnanor.32.106
• Publication Date: 2015-05-06T13:56:35Z
• Authors: Chien Wen Huang; Vasant Kearney; Sina Moeendarbari; Rui Qian Jiang; Preston Christensen; Rakesh Tekade; Xian Kai Sun; Wei Hua Mao; Yao Wu Hao
• Keywords: Radiosensitizer; Clonogenic assay; Biocompatible material

We report in vitro studies on radiotherapy enhancement of hollow gold nanoparticles (HAuNPs), which feature a 50 nm core and 30 thick polycrystalline shell. A clonogenic cell survival assay was used to assess radiation dose breast cancer MDA-MB-231 cells. Cells were cultured culture solution pegylated HAuNPs added. No cytotoxicity the observed at nanoparticle concentration up 4.25×10 9 nanoparticles/ml (350 μM Au concentration). small animal X-ray irradiator clinical linear accelerator irradiate HAuNP-treated control groups. It shows that damage cells is significantly enhanced when are exposed HAuNPs. This first time AuNPs with diameter larger than 100 has been studied for their radiosensitizing effects. In settings, we envision could be intratumorally injected into tumors, more realistic practical usage as radiosensitizer passive accumulation tumors using permeability retention effect or active targeting. Larger particles favored intratumoral injection approach since tend retained sites, less likely diffusing surrounding normal tissues. So, this proof-of-concept evaluation promising potential use therapy sensitizer cancers.