Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft

• DOI: 10.4037/ajcc2019976
• Publication Date: 2019-11-01T09:15:20Z
• Authors: Yuling Chen; Sai Lu; Ying Wu; Yuzhi Shen; Haibo Zhao; Shu Ding; Xinwei Feng; Li Sun; Xiangjun Tao; Jinglian Li; Ruiying Ma; Weiwei Liu; Fangqin Wu; Yadi Feng
• Keywords: Univariate analysis

Serum level of interleukin 6 (IL-6) is known to be associated with postoperative delirium. However, no consensus has emerged on the time point at which IL-6 may predict delirium after coronary artery bypass graft surgery.To compare trends in levels patients and without examine relationship between different times graft.A prospective cohort study who underwent their first elective isolated November 2013 August 2015 a cardiac intensive care unit Beijing, China. Concentrations were measured before operation 6th, 12th, 18th hours. Participants assessed for twice daily 5 days. Univariate multivariate logistic regression analyses done determine associations points, changes levels, occurrence delirium.Postoperative was diagnosed 85 266 (32%). Levels significantly higher than it hours (P = .03, .004, .001, respectively). Change (odds ratio, 2.97; 95% CI, 1.20-7.31; P .02) 583 pg/mL or hour 5.20; 1.84-14.70; .002) incidence delirium.Interleukin (≥ pg/mL) serve as potent predictor patients.