International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update

• DOI: 10.4046/trd.2024.0198
• Publication Date: 2025-02-07T02:07:36Z
• Authors: Désirée Larenas-L...; Chin Kook Rhee; Alan Altraja; John Busby; Trung N. Tran; Eileen Wang; Todor A. Popov; Patrick D. Mitchell; Paul E. Pfeffer; Roy Alton Pleasants; Rohit Katial; Mariko Siyue Koh; Arnaud Bourdin; Florence Schleich; Jorge Máspero; Mark Hew; Matthew J. Peters; David J. Jackson; George C. Christoff; Luis Perez-de-Llano; Ivan Cherrez-Ojeda; João A. Fonseca; Richard W. Costello; Carlos A. Torres-...; Piotr Kuna; Andrew N. Menzies...; Neda Stjepanovic; Peter G. Gibson; Paulo Márcio Pitrez; Celine Bergeron; Celeste M. Porsbjerg; Camille Taillé; Christian Taube; Nikolaos G. Papad...; Andriana I. Papai...; Sundeep Salvi; Giorgio Walter Ca...; Enrico Heffler; Takashi Iwanaga; Mona S. Al-Ahmad; Sverre Lehmann; Riyad Al-Lehebi; Borja G. Cosio; Diahn-Warng Perng; Bassam Mahboub; Liam G. Heaney; Pujan H. Patel; Njira Lugogo; Michael E. Wechsler; Lakmini Bulathsin...; Victoria Carter; Kirsty Fletton; David L. Neil; Ghislaine Scelo; David B. Price

The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As first global registry for adults with asthma, ISAR enabled individual registries standardize pool their data, creating a comprehensive, harmonized dataset sufficient statistical power address key research questions knowledge gaps. Today, is largest repository real-world data on curating nearly 35,000 patients from 28 countries worldwide, has become leading contributor research. Research using provided valuable insights characteristics burdens risk factors, treatment effectiveness, barriers specialist care, which are collectively informing improved management. Besides changing clinical thinking via research, aims practice through initiatives that improve quality care. In 2024, refined essential variables enhance launched QISAR, web-based acquisition reporting system, integrates collection consultations enables longitudinal tracking at patient, center, population levels. Quality improvement priorities include collecting standardized during optimizing journeys QISAR integrating primary/secondary pathways expedite management facilitate trial recruitment. envisions future timely referral initiation biologic therapy can obviate long-term systemic corticosteroid use enable more achieve remission.