Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

• DOI: 10.4049/jimmunol.128.2.811
• Publication Date: 2022-12-31T23:31:06Z
• Authors: H J Showell; P H Naccache; P Borgeat; S Picard; P Vallerand; E L Becker; R I Sha'afi
• Keywords: Leukotriene B4; Cytochalasin B; Cytochalasin

Abstract We have described in det ail the secretory activity of leukotriene B4 toward rabbit neutrophils. Leukotriene rapidly and vigorously degranulates This is stereospecific, cytochalasin B-dependent, enhanced by extracellular calcium. Pretreatment with deactivates neutrophils, i.e., cells so treated do not respond to stimulation an additional bolus B4. In addition, sharply dependent on simultaneous presence B. Rabbit neutrophils therefore exhibit previously desensitization effect these other discussed respects characteristics B4-induced degranulation are strikingly similar those chemotactic factors. These results support hypothesis that mediates, at least part, secretory, possibly other, activities