Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptions.

Male Mice, Inbred BALB C 0303 health sciences Placenta Fetal Resorption Lymphocyte Activation Immunotherapy, Adoptive 3. Good health Mice 03 medical and health sciences Mice, Inbred DBA Pregnancy Histocompatibility Antigens Mice, Inbred CBA Animals Cytokines Pregnancy, Animal Female Lymphocyte Culture Test, Mixed
DOI: 10.4049/jimmunol.152.10.4903 Publication Date: 2022-12-31T10:28:37Z
ABSTRACT
Observations on maternal recognition of the fetus and demonstration effects cytokines reproductive events led to "immunotrophism" model, which suggests that immune fetally-derived Ags results in release promote growth placenta; any disturbance this balance could result deleterious consequences for placenta and, turn, fetus. We have focused our attention murine CBA/J x DBA/2 model spontaneous abortions compared them with normal CBA BALB/c pregnancies. Our indicate extent stimulation strain lymphocytes response stimulator placental cells mixed lymphocyte-placenta reactions (MLPR) was much higher mating combination abortion-prone combination. Cytokine analysis supernatants from MLPR indicates there is significantly production TNF-alpha, IFN-gamma, IL-2 than Furthermore, MLPR-stimulated induce resorptions pregnant mice; stimulated by placentas high rates fetal resorptions, but do not. Together, these suggest immunologically mediated probably improper or inappropriate responses Ags. observations also such are cytokines.
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