Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris.

• DOI: 10.4049/jimmunol.155.8.4078
• Publication Date: 2022-12-31T12:34:43Z
• Authors: A Menssen; P Trommler; S Vollmer; D Schendel; E Albert; L Gürtler; G Riethmüller; J C Prinz
• Keywords: Pathogenesis

Abstract Psoriasis vulgaris is an inflammatory skin disease characterized by excessively increased keratinocyte proliferation. Several lines of evidence support the idea that T cells infiltrating psoriatic lesions play a vital role in pathogenesis disease. To establish whether lesional accumulation and activation lymphocytes reflect specific local immune response, TCR beta-chain variable (V beta) region gene usage was studied chronic plaques, normal skin, paired blood lymphocytes. By semiquantitative PCR, we found overexpression either or both V beta 2 6 families repertoires lesions. However, sequence analysis complementarity-determining 3 (CDR3) these demonstrated marked oligoclonality only lesions, not The amino acid sequences clones revealed certain conserved junctional motifs were shared different patients. A second biopsy taken from one psoriasis patients 18 mo later anatomical site disclosed same again dominating. These data suggest expressing prevailing genes represent oligoclonal cell subset expanded few progenitor response to Ag They are derived polyclonal population that, expression TCR, appears be predisposed for homing skin.