Phospholipase Cγ2 Is Essential for Specific Functions of FcεR and FcγR

• DOI: 10.4049/jimmunol.169.12.6743
• Publication Date: 2014-04-21T00:33:07Z
• Authors: Renren Wen; Shiann-Tarng Jou; Yuhong Chen; Angelica Hoffmeyer; Demin Wang
• Keywords: Fc receptor

Abstract Phospholipase Cγ2 (PLCγ2) plays a critical role in the functions of B cell receptor cells and FcRγ chain-containing collagen platelets. Here we report that PLCγ2 is also expressed mast monocytes/macrophages activated by cross-linking FcεR FcγR. Although PLCγ2-deficient mice have normal development numbers monocytes/macrophages, demonstrate essential for specific While mitogen-activated protein kinase activation cytokine production at mRNA levels, mutant impaired FcεR-mediated Ca2+ flux inositol 1,4,5-trisphosphate production, degranulation, secretion. As physiological consequence effect deficiency, are resistant to IgE-mediated cutaneous inflammatory skin reaction. Macrophages from no detectable FcγR-mediated flux; however, phagocytosis. Moreover, nonredundant