Role of NKT cells in the placenta and uterus of pregnant mice infected by Chlamydia trachomatis (42.5)

• DOI: 10.4049/jimmunol.178.supp.42.5
• Publication Date: 2023-01-02T05:17:18Z
• Authors: Colette Kanellopo...; Christiane Delarbre; Mohamed Habbeddine; Philippe Verbeke; René Moutier; David Ojcius
• Keywords: CD1D

Abstract In order to study the role of maternal NKT cells against a Chlamydia infection during pregnancy, we have compared CD1d-deficient, C57Bl/6 (B6) mice wild type controls, in presence or absence infection. We examined expression several molecules known be important for cell function, uterus and placenta. focused our on NKG2A, NKG2C NKG2D receptors, their ligands Qa-1 Rae-1 co-receptors CD94, DAP10 DAP12. also studied perforin, granzyme B, osteopontin cytokines such as TNF alpha, interferon gamma IL1 beta, Our results suggest that CD1d-restricted do not play major control infection, intensity duration were comparable CD1d-deficient mice. However, found caused an increase invariant (iNKT) placenta B6 mice, measured by characteristic TCR Valpha14-Jalpha18 chain. Correlatively, lead organ-specific modulations markers, which differed from those observed Supported NIH grant number 5 R21 A1060725-02, CNRS Universities Paris 6 7.