CD11cHI macrophages are specialized APCs in the early human placenta (169.45)

• DOI: 10.4049/jimmunol.186.supp.169.45
• Publication Date: 2023-01-01T05:37:19Z
• Authors: Brandy Houser; Leigh Guerin; Vernon Wu; Annemiek DeJong; D Branch Moody; Jack Strominger
• Keywords: CD11c; CD1; Decidua

Abstract The human maternal-fetal interface is a unique environment by which there necessary establishment of maternal tolerance to fetal antigens as well uterine spiral artery remodeling and placental growth. Decidual macrophages (dMΦs) comprise approximately 20% all leukocytes at this interface. Previously we identified two distinct populations based upon CD11c have been termed, CD11cHI CD11cLO MΦs (J Immunol. 2011; 186(4)). Based microarray analysis, dMΦs were shown significantly divergent functions. Using DQ-BSA assay demonstrate that cells process exogenous protein efficiently while processing very low. Furthermore, several CD1 molecules are expressed on the surface including CD1a, CD1c CD1d. non-polymorphic glycolipid-presenting no known function In order determine functional relevance, utilized established CD1-specific T cell clones ligands for CD1a [CD8.2, dideoxymycobactin (DDM); CD8.1, mannosyl-β1-phosphomycoketide (MPM)] respectively. dMΦs, but not found specifically stimulate these clones. Thus, data suggest may in different antigen-presenting systems during early pregnancy, peptide presentation glycolipid presentation.