Effect of self antigen specific CD4+ T cell precursor frequency on the anti-tumor immune response: Implications for adoptive T cell therapy (P2040)

• DOI: 10.4049/jimmunol.190.supp.132.10
• Publication Date: 2023-01-01T06:34:58Z
• Authors: Nicole Malandro; Sadna Budhu; Judith Murphy; Gabrielle Rizzuto; Alan Houghton; Taha Merghoub; Jedd Wolchok
• Keywords: Adoptive Cell Transfer

Abstract Current approaches to cancer immunotherapy aim enhance the natural T cell response against tumors; however, these treatments may fall short due negative selection of tumor antigen specific cells. To determine how frequency CD4+ cells shape an anti-tumor we have developed a model in which precursor number can be manipulated mice bearing implantable melanoma through adoptive transfer We previously shown that lower frequencies CD8+ for gp100 generate most productive intraclonal competition at higher concentrations. Unlike cells, greater quantities TRP-1 results better regression. The activation and expansion high is diminished compared frequencies, indicates occurrence competition. believe observed differences eradication are increased infiltration into when present with favoring preferential accumulation Foxp3+ regulatory both periphery. Further understanding develop effector implications use improvement therapy.