A novel B7 family member, B7-H3 is preferentially expressed on the cell surface of synovial monocytes in rheumatoid arthritis (RA) (BA7P.153)

• DOI: 10.4049/jimmunol.194.supp.115.13
• Publication Date: 2022-12-30T17:24:42Z
• Authors: Bo Ruem Yoon; Yeon-Ho Chung; Dong Hyun Kim; Bonah Kim; Su-Jin Yoo; Doo Hyun Chung; Seong Wook Kang; Won-Woo Lee
• Keywords: Monocyte; Pathogenesis

Abstract B7-H3, a newly identified B7 family member, has functional duality as T-cell costimulator and coinhibitor that fine-tunes mediated immune responses. Given B7-H3 expression on human monocytes dendritic cells is enhanced by inflammatory cytokines, its potential inmmunoregulatory role at sites of inflammation been suggested. Monocytes also play crucial roles in the pathophysiology various autoimmune diseases. However, immunological RA not defined. We aimed to investigate possible monocyte pathogenesis RA. Synovial monocytes, but peripheral patients predominantly express surface B7-H3. The 4Ig isoform exclusively induced cell surface, whereas 2Ig constitutively expressed intracytoplasmic region both synovial monocytes. knockdown experiments provide evidence an inhibitory effect IFN-γ production CD4 memory cells. Moreover, level inversely correlates with clinical parameters such CRP levels, ESR, DAS28. Our findings demonstrate activation-induced inhibit Th1-mediated responses immunomodulatory thereby affecting