Tumor-associated CAIC5 suppresses NKT cell proliferation and cytokine production

• DOI: 10.4049/jimmunol.196.supp.142.14
• Publication Date: 2023-01-01T10:33:51Z
• Authors: Inhak Choi; Eungchang Lee; Keunok Jung; Heejung Kim
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

Abstract In the previous study, we identified cancer-associated immune checkpoint 5 (CAIC5) as a new co-inhibitory molecule belonging to B7-related family. Typically, CAIC5 is expressed in tissue macrophages including Kupffer cells and peritoneal macrophages. We also found out human fusion protein greatly suppressed proliferation cytokine production T NKT respective stimulation assay. Since expression was tumor microenvironment, examined impact of cell-associated on cell function. CAIC5-expressing cancer that are pulsed with alpha-galactosylceramide (a-Gal) IFN-g proliferation. KO mice were systemically injected a-Gal enhanced cells. Furthermore, WT showed poor survival compared those mock-expressing similarly coculture line. Therefore, can be an important part mechanisms for escape.