Regulation of effective vs. ineffective B cell responses to chronic viral infections.

• DOI: 10.4049/jimmunol.196.supp.147.2
• Publication Date: 2023-01-01T10:36:12Z
• Authors: Ryan P Staupe; E John Wherry
• Keywords: Chronic infection

Abstract Human immunodeficiency virus (HIV) and hepatitis C (HCV) are chronic viral infections that cause significant morbidity mortality worldwide. Current efforts to vaccinate against these pathogens have been unsuccessful failed induce effective neutralizing antibodies capable of mediating sterilizing immunity. Natural HIV HCV infection elicits the production affinity matured class-switched target proteins. While can drive evolution, they ineffective at controlling infection. Moreover, it is now clear evolution antibody responses, B cells produce them, during radically different than those generated by acute or vaccination. Despite observations, little known about underlying mechanisms cell differentiation control We developed a novel technique allows us track virus-specific response in lymphocytic choriomeningitis (LCMV) model, mouse model Using this we found does not skewing plasma fate away from germinal center but induces robust an antigen-level T-cell dependent manner. These results suggest altered early may contribute temporal delay development responses