IL-17A-producing CD4+Foxp3+ T cells in chronic pulmonary aspergillosis

• DOI: 10.4049/jimmunol.198.supp.125.24
• Publication Date: 2023-01-01T10:48:17Z
• Authors: Min Kyung Jung; Shin Myung Kang; Jeong-Eun Kwak; Eui-Cheol Shin
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Abstract Chronic pulmonary aspergillosis (CPA) is a severe disease caused by aspergillus fumigatus infection. However, immune responses in CPA patients remained to be elucidated. In humans, the CD4+Foxp3+regulatory T cell (Treg) population are classified into following three subsets based on their expression of CD45RA and Foxp3: CD45RA+Foxp3lo resting Treg cells (subset I), CD45RA−Foxp3high activated II), CD45RA−Foxp3locytokine-secreting non-suppressive III). present study, we investigated these CD4+Foxp3+cell clinical implication patients. The frequency total CD4+Foxp3+ did not differ between healthy controls. Whereas subset I or II also two groups, III was significantly increased compared with Interestingly, IL-17A production observed cells, correlated from CD4+ population. Moreover, found that better prognosis, evaluated less hospitalization incident, associated higher among summary, IL-17A-producing IL-17A+ related prognosis. We suggest III) may have role Th17 regulation antifungal