Microbiota Regulation of Pro-atherogenic Phagocytes − Separating Metabolic and Inflammatory Mechanisms.

• DOI: 10.4049/jimmunol.200.supp.108.20
• Publication Date: 2023-01-01T11:12:31Z
• Authors: Sahar Eshghjoo; Yufang Ding; Carrie Hunt; Arul Jayaraman; Robert Christophe...
• Keywords: Foam cell; Proinflammatory cytokine

Abstract A significant hallmark of the chronic inflammatory disease, atherosclerosis, is accumulation pro-inflammatory M1-like macrophages (macs) and dendritic cells (DCs) in coronary arteries that respond to pro-atherogenic stimuli fail digest lipids contribute formation foam atherosclerotic plaques. Mechanisms reduce Mac/DC inflammation, increase lipid degradation, prevent cell are likely decrease progression atherosclerosis. regulate autophagy macs DCs will reveal targets for prevention Mouse models high-fat diets demonstrate a link between microbiota composition development obesity, diabetes, atherosclerosis through several mechanisms best demonstrated by microbiota-dependent production TMAO promotes We have identified tryptophan-derived metabolite, indole, has novel immunomodulatory properties. This strong association led us hypothesis microbiota-derived metabolites GI tract might dietary saturated fat-induced inflammation. To test this hypothesis, we generated bone marrow-derived (BMDMs) (BMDCs) tested effects indole on these context fatty acid-induced investigated cytokine production, M1 macrophage development, metabolic flux. Here, reduces acid-derived inflammation BMDCs BMDMs regulates programming phagocytes inducing level similar rapamycin.