Outcome of ventilator-associated pneumonia: Impact of antibiotic therapy and other factors.

• DOI: 10.4066/amj.20121004
• Publication Date: 2012-01-01
• Authors: Noyal Mariya Joseph; Sujatha Sistla; Tarun Kumar Dutta; Ashok Shankar Badhe; Desdemona Rasitha; Subhash Chandra P...
• Keywords: Ventilator-associated Pneumonia

Ventilator-associated pneumonia (VAP) is the most frequent infection in patients intubated for longer than 48 hours. There a great interest determining factors influencing outcome of VAP, as it may help reducing associated morbidity and mortality. This study aimed to determine impact appropriate antibiotic therapy based on endotracheal aspirate cultures VAP. We have also studied other that influence VAP.A cohort was conducted intensive care units tertiary hospital South India over period 15 months. The VAP assessed by prolongation duration mechanical ventilation and/or death patient.The significantly prolonged with (16.61 ± 8.2 d vs. 8.21 5.9 d, P < 0.0001). receiving partially or totally inappropriate (defined lack coverage one all significant pathogens) were at high risk (Relative risk, 2.00; 95% confidence interval, 1.14 3.52; 0.0008). A delay > 2 days administering first dose (P Infection multi-drug resistant pathogens, polymicrobial time onset did not VAP.Early administration therapy, antibiogram pathogens identified quantitative culture aspirate, could lead an improved ventilator-associated pneumonia.