SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES

• DOI: 10.4067/s0717-97072011000400006
• Publication Date: 2012-03-13T13:05:19Z
• Authors: RAVINESH MISHRA; ANEES A SIDDIQUI; ASIF HUSAIN; MOHD RASHID; ATISH PRAKASH; MUKUL TAILANG; MUNEESH KUMAR; NEETI SRIVASTAVA
• Keywords: Pyridazine

Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons.The final compounds (4a-i) screened for antihypertensive activities non-invasive method using Tail Cuff method.The 4e and 4i showed appreciable activity.