Noncoding RNA small nucleolar RNA host gene 1 promote cell proliferation in nonsmall cell lung cancer

• DOI: 10.4103/0019-509x.154092
• Publication Date: 2015-03-27T08:19:56Z
• Authors: J You; Q Zhou; N Fang; J Gu; Y Zhang; X Li; L Zu
• Keywords: Small nucleolar RNA

Nonsmall cell lung cancer (NSCLC) is the major cause of death worldwide. Increasing evidence shows that noncoding RNAs (ncRNAs) are widely involved in development and progression NSCLC. ncRNA small nucleolar RNA host gene 1 (SNHG1) has not been studied cancer, especially its role remains unknown. Our studies were designed to investigate expression biological significance SNHG1 cancer. may be a novel early diagnosis cancer.Noncoding 7 lines was measured by quantitative real-time polymerase chain reaction. interference approaches used find functions SNHG1. The effect on proliferation evaluated count crystal violet stains.Noncoding significantly upregulated cells when compared with normal bronchial epithelial cells. In addition, vitro assays our results indicated knockdown inhibited proliferation.Our data NSCLC represent new biomarker potential therapeutic target for intervention.