Affection of Single-Nucleotide Polymorphisms in miR-27a, miR-124a, and miR-146a on Susceptibility to Type 2 Diabetes Mellitus in Chinese Han People

• DOI: 10.4103/0366-6999.151112
• Publication Date: 2015-02-09T13:15:53Z
• Authors: Tong-Tong Wang; Yong-Jie Chen; Lu-Lu Sun; Si-Jia Zhang; Zhong-Yu Zhou; Hong Qiao
• Keywords: Adult; Male; 0303 health sciences; Genotype; R; Middle Aged; Epigenetics; Genetic Variation; MicroRNA; Single-Nucleotide Polymorphism; Type 2 Diabetes Mellitus; Polymorphism, Single Nucleotide; 3. Good health; MicroRNAs; Young Adult; 03 medical and health sciences; Asian People; Diabetes Mellitus, Type 2; Medicine; Humans; Original Article; Female; Genetic Predisposition to Disease; Alleles; Aged

Polymorphisms of microRNA (miRNA), as a novel mechanism, are closely associated with disease states by interfering miRNA function. Direct correlations have been identified between single-nucleotide polymorphisms (SNPs) in miRNA, but the effect on type 2 diabetes mellitus (T2DM) onset among Chinese population remains unclear. Therefore, aim this study was to identify common SNPs miR-27a, miR-146a, and miR-124a T2DM population, well explore diabetic pathological mechanisms impact environmental factors.SNPscan technology used genotype 995 patients newly diagnosed 967 controls. Logistic regression analysis performed compare mutation frequencies cases controls.We found no significant all genotypes these miRNAs our research. However, stratification lower risk rs531564GC younger subjects (age < 45 years) (adjusted P = 0.043; odds ratio [OR] 0.73; 95% confidence interval [CI] 0.54-0.99). Furthermore, rs895819CC overweight people (24 ≤ body mass index [BMI] 28) significantly an increased 0.042; OR 1.73; CI 1.02-2.94), while rs2910164 miR-146a not correlated T2DM. The genetic score calculated based number alleles three be total cholesterol 0.021).The acted protective factor decrease years), presence illness BMI 28 kg/m ). might promote affecting expression gene Thus, mimics or inhibitors that directly regulate present promising therapeutic targets.