Overall Blastocyst Quality, Trophectoderm Grade, and Inner Cell Mass Grade Predict Pregnancy Outcome in Euploid Blastocyst Transfer Cycles

• DOI: 10.4103/0366-6999.232808
• Publication Date: 2018-05-21T06:01:19Z
• Authors: Yan-Yu Zhao; Yang Yu; Xiao-Wei Zhang
• Keywords: Blastocyst Transfer; Inner cell mass; Live birth

Background: Despite recent advances that have improved the pregnancy success rates can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological parameters best predict outcomes of single transfer. In addition, most previous studies did exclude effect embryo aneuploidy on blastocysts Thus, present study investigated predictive value various transfer frozen euploid blastocysts. Methods: The retrospectively analyzed 914 cycles were performed at Peking University Third Hospital Reproductive Medical Center between June 2011 and May 2016. expansion, trophectoderm (TE), inner cell mass (ICM) quality assessed based parameters, used to differentiate "excellent", "good", "average", "poor"-quality embryos. relationship these grades was then Chi-square logistic regression tests. Results: For excellent, good, average poor, clinical 65.0%, 59.3%, 50.3% 33.3%, respectively; live-birth 50.0%, 49.7%, 42.3% 25.0%, respectively. Both rate (χ2 = 21.28, P 0.001) 13.50, < increased with overall grade. significantly higher after a exhibited either an A-grade OR B-grade TE, similarly, ICM, than C-grade TE and/or ICM. degree expansion had no apparent or rate. All odds ratio adjusted for patient age, body index, length (years) infertility history, type. Conclusions: A shown correlate strongly optimal outcomes. thus supports use described ICM augment current selection criteria.